摘要

【资料图】

自从1965年发现B细胞以来(Cooper et al. 1965)，我们对B细胞发育、成熟和功能的理解取得了长足进步。目前，已经鉴定出许多B细胞亚群，包括B-1、B-2和调节性B细胞。B-1细胞主要来源于胎肝(fetal liver)，具体可分为B-1a和B-1b亚群；B-2细胞起源于骨髓(BM)，可进一步分为滤泡B(FOB)和边缘区B(MZB)细胞；调节性B细胞(Bregs)常认为通过产生抗炎细胞因子IL-10等来抑制免疫反应。B细胞的耐受性是经由若干检查点建立，包括BM中的B细胞发育（中枢耐受）以及外周B细胞成熟和激活（外周耐受）。本章将重点关注B-1和B-2细胞，介绍它们发育和成熟过程中重要的调控过程。

关键词

#Ig gene #V(D)J recombination #Follicular B #Marginal zone B  #B-1

#Ig基因 #V(D)J重排 #滤泡B细胞 #边缘区B细胞 #B-1细胞

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